• Progesterone is primarily produced by the corpus luteum in the ovary just prior to and after ovulation.
  • It is also produced in large quantities by the placenta during pregnancy, while produced all the time by the adrenal glands.
  • Progesterone may enhance estrogen activity while also moderating symptoms of estrogen excess such as water retention, fat accumulation, uterine bleeding, and mood swings.
  • Progesterone helps promote thyroid activity, and may also stimulate cells (osteoblasts) necessary for bone building.
  • Replacement with natural progesterone protects against uterine and breast cancer plus osteoporosis.
  • Progesterone reduces symptoms of menopause.
  • Progesterone occurs naturally with estrogen and should be prescribed concurrently to balance estrogen.